For local Luminal A-like cases, chemotherapy and endocrine therapy were recommended if Prosigna® testing classified them as Luminal A with high/intermediate risk or upgraded to Luminal B subtype.Ĭonclusion: IRR between Prosigna® subtypes and surrogate subtyping was fair to moderate depending on surrogate subtyping method and center. Chemotherapy and endocrine therapy were recommended to 44.2% and 88.6% of Prosigna® Luminal A and Luminal B cases, respectively. Best agreement occurred between Prosigna® (53.8% Luminal A/44.5% Luminal B) and C1 von Minckwitz subtyping (Cohen’s kappa= 0.455). In contrast to local and C1, C6 surrogate subtyping assigned >66.7% of cases to Luminal A-like. According to local IHC, 35.4% were Luminal A-like, 64.6% Luminal B-like (local von Minckwitz subtype: 31.9% Luminal A-like/68.1% Luminal B-like). Results: For 119 cases, Prosigna® and surrogate subtyping were available. Moreover, impact of Prosigna® test results on treatment decision on chemotherapy was studied. Prosigna® molecular subtyping was compared with local and two central (C1 and C6) surrogate subtypes utilizing inter-rater reliability (IRR) analysis. Methods: 142 BCs with intermediate clinico-pathological risk were investigated using Prosigna® testing in a prospective multicenter study. In intermediate risk hormone receptor (HR) positive, HER2 negative BC, decision for adjuvant chemotherapy can be supported by multigene expression tests. *Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), CCC Erlangen-EMN, Germanyīackground & objectives: In breast cancer (BC), therapy decision depends on prognostic and predictive biomarkers including surrogate subtyping by immunohistochemistry (IHC)& grading. Molecular subtyping of invasive breast cancer using PAM50-based multigene expression testing - comparison with surrogate subtyping by immunohistochemistry and grading and influence on oncologist’s decision on systemic therapy in a real world setting It can be used to identify patients with ER low positive whose clinicopathological characteristics are similar to ER-negative patients and will help guide individualized and precise treatment of ER low positive breast cancer patients. Among patients with ER low positive, those with negative predicted results have lower expression of ESR1 mRNA, cannot benefit from endocrine therapy and have a poor prognosis.Ĭonclusion: Based on clinicopathological characteristics, we have developed and verified a nomogram that predicts the expression status of ER in patients with invasive breast cancer. 164 (63.08%) patients had negative predicted results, and 96 (36.92%) patients had positive predicted results. The nomogram was used to predict subgroups of patients with ER low positive breast cancer. By calculating the Yorden index, the best cut-off value for predicting ER expression status is 0.59.
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The AUC of the nomogram in the training cohort and validation cohort were 0.804 (95% CI 0.750-0.858) and 0.828 (95% CI 0.752-0.903), respectively. Among these, 5 (20%) patients were clinically diagnosed as PPCM or dilated cardiomyopathy, where an echocardiology showed an ejection fraction 20/10 HPF, tumour infiltrating lymphocytes>40%, and necrosis are often ER-negative. Results: Among the 425 autopsies performed, 25 patients (5.8%) were diagnosed as PPCM on clinico-pathological basis. Samples were taken from right and left ventricular myocardia and examined by routine and/or special staining techniques. The hearts were dissected by the inflow-outflow method. Analysed details were demographics, duration and type of symptoms, clinical diagnosis and investigations.
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Methods: We conducted a retrospective autopsy study of pathologically diagnosed cases of PPCM in maternal deaths in tertiary centre from 2012 to 2020. Aim is to identify the clinical presentation and pathological features of PPCM among the maternal deaths. Hospital, Indiaīackground & objectives: Peripartum cardiomyopathy (PPCM) is an idiopathic left ventricular systolic dysfunction leading to cardiac failure in last trimester of pregnancy or in the postpartum period. Myocardial pathology in pregnancy - an autopsy study